In the Pinacoteca comunale of Città di Castello you can now admire the Standard of the Holy Trinity (Gonfalone della Santissima Trinità) (1502), while, in Perugia in the San Severo chapel there is the fresco representing the Holy Trinity with Saints (Trinità e santi) (1505).
At the same time, Raphael's stay in the region was an inspiration for artists who came into direct contact with him or his works, remaining deeply influenced.
Some of them incorporated the innovations introduced in a more formal manner, such as Francesco da Città di Castello, others were struck by them, such as Giannicola di Paolo, Giovan Battista Caporali and Eusebio da San Giorgio.
With the Perugians Domenico Alfani and Berto di Giovanni, Raphael began a real collaborative relationship, enough to provide them with drawings and keep in touch with them after leaving Perugia.
To this generation is added Giovanni di Pietro, known as Lo Spagna, who slowly approached the ways of the painter from Urbino, to become the gateway for the penetration of the Raphaelesque models in the Valle Umbra, between Trevi and Todi.
The second moment in the Raphaelesque influence is characterized by figures such as Vincenzo Tamagni, Giovanni da Spoleto, but, above all, Giulio Romano, Jacopo Siculo, Raffaellino del Colle and, at least initially, Dono Doni.